Structural basis for potent antibody-mediated neutralization of human cytomegalovirus
نویسندگان
چکیده
منابع مشابه
Rapid neutralization assay for human cytomegalovirus antibody.
Human cytomegalovirus induces the appearance of immediate early antigens in infected cells 1 h after infection. This provided the basis for the development of a rapid neutralization assay for cytomegalovirus antibody which was able to yield results within a single day. Indirect immunofluorescence to visualize immediate early antigen-positive cells was applied to the rapid determination of cytom...
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Glycoprotein D (gD) of herpes simplex virus (HSV) binds to a host cell surface receptor, which is required to trigger membrane fusion for virion entry into the host cell. gD has become a validated anti-HSV target for therapeutic antibody development. The highly inhibitory human monoclonal antibody E317 (mAb E317) was previously raised against HSV gD for viral neutralization. To understand the s...
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ژورنال
عنوان ژورنال: Science Immunology
سال: 2017
ISSN: 2470-9468
DOI: 10.1126/sciimmunol.aan1457